AZD5582

• 常用名: AZD5582
• 英文名: AZD5582
• CAS号: 1258392-53-8
• 分子量: 1015.289
• 密度: 1.3±0.1 g/cm3
• 沸点: 1207.3±65.0 °C at 760 mmHg
• 分子式: C₅₈H₇₈N₈O₈
• 熔点: N/A
• 闪点: 683.9±34.3 °C

AZD5582用途

AZD5582是二聚化Smac mimetics，IAPs抑制剂，对cIAP1，cIAP2和XIAP的IC50值分别为15，21和15nM。

AZD5582名称

• 中文名: AZD5582
• 英文名: (2S,2'S)-N,N'-{2,4-Hexadiyne-1,6-diylbis[oxy(1S,2R)-2,3-dihydro-1H-indene-2,1-diyl]}bis{1-[(2S)-2-cyclohexyl-2-{[(2S)-2-(methylamino)propanoyl]amino}acetyl]-2-pyrrolidinecarboxamide} (non-preferred name)

AZD5582生物活性

• 描述: AZD5582是二聚化Smac mimetics,IAPs抑制剂,对cIAP1,cIAP2和XIAP的IC50值分别为15,21和15nM。
• 相关类别:
  信号通路 >> 细胞凋亡 >> IAP
  研究领域 >> 癌症
• 参考文献:

  [1]. Hennessy EJ, et al. Discovery of a novel class of dimeric Smac mimetics as potent IAP antagonists resulting in a clinical candidate for the treatment of cancer (AZD5582). J Med Chem. 2013 Dec 27;56(24):9897-919.

  [2]. Zhuang J, et al. Selective IAP inhibition results in sensitization of unstimulated but not CD40-stimulated chronic lymphocytic leukaemia cells to TRAIL-induced apoptosis. Pharmacol Res Perspect. 2014 Dec;2(6):e00081.

AZD5582物理化学性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 1207.3±65.0 °C at 760 mmHg
• 分子式: C₅₈H₇₈N₈O₈
• 分子量: 1015.289
• 闪点: 683.9±34.3 °C
• 精确质量: 1014.594238
• LogP: 9.22
• 蒸汽压: 0.0±0.3 mmHg at 25°C
• 折射率: 1.622
• 储存条件: 2-8℃

AZD5582英文别名

• (2S,2'S)-N,N'-{2,4-Hexadiyne-1,6-diylbis[oxy(1S,2R)-2,3-dihydro-1H-indene-2,1-diyl]}bis{1-[(2S)-2-cyclohexyl-2-{[(2S)-2-(methylamino)propanoyl]amino}acetyl]-2-pyrrolidinecarboxamide} (non-preferred name)
• 2-Pyrrolidinecarboxamide, N,N'-[2,4-hexadiyne-1,6-diylbis[oxy[(1S,2R)-2,3-dihydro-1H-indene-2,1-diyl]]]bis[1-[(2S)-2-cyclohexyl-2-[[(2S)-2-(methylamino)-1-oxopropyl]amino]acetyl]-, (2S,2'S)-
• AZD5582