| 常用名 | 可伐利单抗 | CAS号 | 1917321-26-6 |
|---|---|---|---|
| 价格 | ¥需询单/100ug ¥需询单/500ug | 纯度 | 95.0% |
| 备货期 | 需询单 | 库存 | 现货 |
| 产品详情(用途,包装等)
用途: Crovalimab (SKY59; RO7112689) is a novel humanized antibody against C5 in a pH-dependent manner with KDs of 15.2 nM and 16.8 μM at pH 7.4 and 5.8, respectively. Crovalimab binds human FcRn with great affinity (KD: 17 μM at pH 6.0). Crovalimab can block cleavage of C5 by the C5 convertase and inhibite the activity of a C5 variant (p.Arg885His). Crovalimab inhibits C5b-9 formation significantly in all three complement pathways, the classical pathway (CP), lectin pathway (LP), and alternative pathway (AP). Crovalimab has the potential for paroxysmal nocturnal hemoglobinuria (PNH) and complement-mediated diseases research[1][2]. 物理化学性质: CAS号:1917321-26-6 常用中文名:可伐利单抗 常用英文名:Crovalimab 分子式: 分子量: 密度:N/A 沸点:N/A 熔点:N/A 闪点:N/A |