ADL5859 HCl
更新时间：2025-08-31 16:24:11
采购访问：66次
| 常用名 | N,N-二乙基-4-(5-羟基螺[2H-1-苯并吡喃-2,4'-哌啶]-4-基)苯甲酰胺盐酸盐 | CAS号 | 850173-95-4 |
|---|---|---|---|
| 价格 | ￥需询单/1g | 纯度 | 98.9% |
| 备货期 | 1天 | 库存 | 现货 |
| 产品详情（用途，包装等）
ADL5859 agonizes δ-opioid receptor with a 1000-fold selectivity than µ- or κ-opioid receptor with Ki of 32 nM and 37 nM, respectively.ADL5859 displays weak inhibitory activity at the hERG channel with an IC50 of 78 μM. The EC50 of ADL5859 against δ opioid receptor is 20 nM. At the screening dose of 3 mg/kg p.o., ADL5859 produces 100% reversal of hyperalgesia in the inflamed paw. The oral ED50 of ADL5859 in the FCA mechanical hyperalgesia assay is 1.4 mg/kg. The antihyperalgesia produced by ADL5859 (3 mg/kg, p.o.) is reversed by pretreatment with the δ opioid antagonist naltrindole (0.3 mg/kg s.c.), thus demonstrating a δ receptor mediated effect.In the rat Forced swim assay, ADL5859 (3 mg/kg p.o.) produces robust antidepressant-like activity, as evidenced by a significant decrease in the time spent immobile and a significant increase in the time spent swimming. The bioavailability of ADL5859 (3 mg/kg p.o.) in rats and dogs is 33% and 66%, respectively.ADL5859 efficiently reduces inflammatory and neuropathic pain mainly by recruiting δ-opioid receptors expressed by peripheral Nav1.8-expressing neurons.For the detailed information of ADL5859 HCl, the solubility of ADL5859 HCl in water, the solubility of ADL5859 HCl in DMSO, the solubility of ADL5859 HCl in PBS buffer, the animal experiment (test) of ADL5859 HCl, the cell expriment (test) of ADL5859 HCl, the in vivo, in vitro and clinical trial test of ADL5859 HCl, the EC50, IC50,and Affinity of ADL5859 HCl, Please contact DC Chemicals.. |
上海源溪生物科技有限公司
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商品数：14107件
电话：58447131
地址：浦东新区金豫路100号
地区： 上海市 上海市 浦东新区
联系人：赖经理
联系人电话：13564518121
邮件：order@dcchemicals.com
网址：http://www.biomedgen.cn
主要市场：中国、美洲、亚洲、欧洲
年贸易额：1000万元-5000万元
外贸占销售比例：20%
主要合作伙伴：
- 上海源溪生物科技有限公司
- 上海市 上海市 浦东新区
- 产品名：ADL5859 HCl
- 价格： ￥需询单/1g
- 纯度：98.9%
- 备货期：1天
- 联系人：赖经理
- 上海阿拉丁生化科技股份有限公司
- 上海市 上海市 浦东新区
- 产品名：ADL5859 HCl
- 价格： ￥1544.9/10mg ￥294.9/1mg ￥926.9/5mg ￥1138.9/1ml
- 纯度：98.0%
- 备货期：1天
- 联系人：阿拉丁
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N,N-二乙基-4-(5-羟基螺[2H-1-苯并吡喃-2,4'-哌啶]-4-基)苯甲酰胺盐酸盐生产厂家
参考价格：$174/10mM*1mLinDMSO