| 常用名 | Vidofludimus | CAS号 | 717824-30-1 |
|---|---|---|---|
| 价格 | ¥8000.0/1g | 纯度 | 98.0% |
| 备货期 | 需询单 | 库存 | 现货 |
| 产品详情(用途,包装等)
用途: Vidofludimus(4SC-101; SC12267) is a novel immunosuppressive drug that inhibits DHODH; inhibits IL-17 secretion in vitro independently of effects on lymphocyte proliferation.IC50 value:Target: DHODH inhibitorin vitro: 4SC-101 is a potent inhibitor of human DHODH, inhibits lymphocyte proliferation, and uniquely blocks phytohemagglutinin-stimulated IL-17 production by lymphocytes [2].in vivo: In vivo Vido treatment alone most effectively reduced macroscopic and histological pathology and the numbers of CD3+ T cells. In contrast, similarly reduced nuclear signal transducer and activator of transcription 3 (STAT3) binding and IL-17 levels were observed from animals treated with Vido alone and Vido + Uri. Vido improves TNBS-induced colonic inflammation by a unique dual mode of action [1]. Oral administration of 4SC-101 effectively improved both chronic DSS and acute TNBS colitis in mice. In these colitis models the overall efficacy profile of 4SC-101 was similar to that of dexamethasone [2]. 物理化学性质: CAS号:717824-30-1 常用中文名:Vidofludimus 常用英文名:Vidofludimus 分子式:C20H18FNO4 分子量:355.360 密度:1.4±0.1 g/cm3 沸点:567.5±50.0 °C at 760 mmHg 熔点:N/A 闪点:297.0±30.1 °C 储存条件:-20℃ |