Noopept
更新时间：2022-08-12 10:12:27
| 常用名 | N-(1-(苯基乙酰基)-L-脯氨酰)甘氨酸乙酯 | CAS号 | 157115-85-0 |
|---|---|---|---|
| 价格 | ￥需询单/400kg | 纯度 | 99.0% |
| 备货期 | 需询单 | 库存 | 现货 |
| 产品详情（用途，包装等）
用途： Noopept (GVS-111) is a medication promoted and prescribed in Russia and neighbouring countries as a nootropic.IC50 Value:Target: in vitro: Nooglutil exhibits pharmacologically significant competition with a selective agonist of AMPA receptors ([G-3H]Ro 48-8587) for the receptor binding sites (with IC50 = 6.4 +/- 0.2 microM), while the competition of noopept for these receptor binding sites was lower by an order of magnitude (IC50 = 80 +/- 5.6 microM) [1]. GVS-111 significantly increased neuronal survival after H(2)O(2)-treatment displaying a dose-dependent neuroprotective activity from 10 nM to 100 microM, and an IC(50) value of 1.21+/-0.07 microM. GVS-111 inhibited the accumulation of intracellular free radicals and lipid peroxidation damage in neurons treated with H(2)O(2) or FeSO(4), suggesting an antioxidant mechanism of action [2].in vivo: N-Phenylacetyl-L-prolylglycine ethyl ester (GVS-111) administered intravenously at a dose of 0.5 mg/kg/day, for the first time 1 h after ischaemic lesion and then for 9 post-operative days, with the last administration 15 min before testing, attenuated the deficit [3]. GVS-111 itself was not found in rat brain 1 h after 5 mg/kg i.p. administration up to limit of detection (LOD) under high performance liquid chromatography (HPLC) conditions [4]. The most pronounced antiinflammatory effect of dipeptide was observed on the model of adjuvant arthritis in rats, where the drug administered over 25 days in a daily dose of 0.5 mg/kg (i.m.) or 5 mg/kg (p.o.) significantly reduced the chronic immune inflammation (on the 12th day, by 94.0 and 74.1%, respectively) [5].Toxicity: Noopept administered in this dose range induced no irreversible pathologic changes in the organs and systems studied and exhibited no allergenic, immunotoxic, and mutagen activity [6]. Clinical trial: Discontinued 物理化学性质： CAS号：157115-85-0 常用中文名：N-(1-(苯基乙酰基)-L-脯氨酰)甘氨酸乙酯 常用英文名：Noopept 分子式：C17H22N2O4 分子量：318.368 密度：1.2±0.1 g/cm3 沸点：547.3±50.0 °C at 760 mmHg 熔点：94.0 to 98.0 °C 闪点：284.8±30.1 °C 储存条件：-20°C |
- 苏州麦轮生物科技有限公司
- 江苏省 苏州市 吴中区
- 产品名：N-(1-(苯基乙酰基)-L-脯氨酰)甘氨酸乙酯
- 价格： ￥2200.0/1kg ￥105000.0/50kg ￥400000.0/200kg ￥需询单/1ton
- 纯度：99.0%
- 备货期：1天
- 联系人：王小姐
- 上海化源世纪贸易有限公司
- 上海市 上海市 普陀区
- 产品名：N-(1-(苯基乙酰基)-L-脯氨酰)甘氨酸乙酯
- 价格：
- 纯度：98.0%
- 备货期：10天
- 联系人：徐经理
- 南通润丰石油化工有限公司
- 江苏省 南通市 崇川区
- 产品名：N-(1-(苯基乙酰基)-L-脯氨酰)甘氨酸乙酯
- 价格： ￥需询单/1kg ￥需询单/1ton
- 纯度：0.0%
- 备货期：1天
- 联系人：曹经理
- 广东翁江化学试剂有限公司
- 广东省 韶关市 翁源县
- 产品名：N-(1-(苯基乙酰基)-L-脯氨酰)甘氨酸乙酯
- 价格： ￥需询单/1kg ￥800.0/100g ￥2400.0/500g ￥240.0/25g
- 纯度：98.0%
- 备货期：需询单
- 联系人：朱丽丹
- 武汉吉鑫益邦生物科技有限公司
- 湖北省 武汉市 东西湖区
- 产品名：N-(1-(苯基乙酰基)-L-脯氨酰)甘氨酸乙酯
- 价格： ￥需询单/500g ￥需询单/1kg ￥需询单/25kg ￥需询单/200kg
- 纯度：0.0%
- 备货期：需询单
- 联系人：周美玲
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参考价格：￥312/250mg