Sunifiram
更新时间：2022-02-11 10:01:38
| 常用名 | 桑尼非拉姆 | CAS号 | 314728-85-3 |
|---|---|---|---|
| 价格 | ￥需询单/1kg | 纯度 | 99.0% |
| 备货期 | 需询单 | 库存 | 询单 |
| 产品详情（用途，包装等）
用途： Sunifiram (DM-235) is a piperazine derived ampakine-like drug which has nootropic effects in animal studies with significantly higher potency than piracetam.IC50 value: Target: in vitro: DM 232 and DM 235 are novel antiamnesic compounds structurally related to ampakines. The involvement of AMPA receptors in the mechanism of action of DM 232 and DM 235 was, therefore, investigated in vivo and in vitro. Both compounds (0.1 mg/kg i.p.) were able to reverse the amnesia induced by the AMPA receptor antagonist NBQX (30 mg/kg i.p.) in the mouse passive avoidance test. At the effective doses, the investigated compounds did not impair motor coordination, as revealed by the rota rod test, nor modify spontaneous motility and inspection activity, as revealed by the hole board test [1]. In mouse hippocampal slices, sunifiram at 10-100 nM significantly enhanced LTP in a bell-shaped dose-response relationship which peaked at 10 nM. The enhancement of LTP by sunifiram treatment was inhibited by 7-chloro-kynurenic acid (7-ClKN), an antagonist for glycine-binding site of NMDAR, but not by ifenprodil, an inhibitor for polyamine site of NMDAR [2].in vivo: OBX mice were administered once a day for 7-12 days with sunifiram (0.01-1.0 mg/kg p.o.) from 10 days after operation with or without gavestinel (10 mg/kg i.p.), which is glycine-binding site inhibitor of N-methyl-d-aspartate receptor (NMDAR) [3]. 物理化学性质： CAS号：314728-85-3 常用中文名：桑尼非拉姆 常用英文名：DM 235 分子式：C14H18N2O2 分子量：246.305 密度：1.2±0.1 g/cm3 沸点：442.0±38.0 °C at 760 mmHg 熔点：N/A 闪点：205.0±19.1 °C 储存条件：2-8℃ |
- 苏州麦轮生物科技有限公司
- 江苏省 苏州市 吴中区
- 产品名：Sunifiram
- 价格： ￥700.0/100g ￥6500.0/1kg ￥160000.0/25kg ￥需询单/100kg
- 纯度：99.0%
- 备货期：1天
- 联系人：王小姐
- 上海阿拉丁生化科技股份有限公司
- 上海市 上海市 浦东新区
- 产品名：DM 235
- 价格： ￥43.9/1g ￥492.9/25g ￥145.9/5g ￥需询单/1g
- 纯度：98.0%
- 备货期：1天
- 联系人：阿拉丁
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参考价格：$66/10mM*1mLinDMSO