Fevipiprant
更新时间：2023-09-03 22:40:50
| 常用名 | 2-(2-甲基-1-(4-(甲基磺酰基)-2-(三氟甲基)苄基)-1H-吡咯并[2,3-b]吡啶-3-基)乙酸 | CAS号 | 872365-14-5 |
|---|---|---|---|
| 价格 | ￥需询单/1g | 纯度 | 98.0% |
| 备货期 | 需询单 | 库存 | 询单 |
| 产品详情（用途，包装等）
用途： Fevipiprant(QAW039) is a selective, potent, reversible competitive CRTh2 antagonist with an in vitro dissociation constant KD value of 1.1nM at the CRTh2 receptor and an IC50 value of 0.44 nM for inhibition of PGD2-induced eosinophil shape change in human whole blood.IC50:0.44 nM(PGD2-induced eosinophil shape change)Kd value:1.1nM(CRTh2 receptor)[1]In vitro: CRTh2-mediated shape change in eosinophils was used to profile QAW039 in whole blood and represents a physiologically relevant environment. The comparable IC50 values for QAW039 in the whole blood and isolated shape-change assays are consistent with its lower plasma-protein binding and its relatively slow dissociation kinetics that drive its increased potency .QAW039 is highly potent in whole-blood systems, with the IC50 value obtained consistent with the affinity values calculated from radioligand experiments. In a further disease-relevant cellular context, the potency of QAW039 in the isolated Th2 cell cytokine inhibition assay is consistent with its CRTh2 receptor affinity, and, as with eosinophil assay readouts, this represents an improved potency compared with QAV680[2]. 物理化学性质： CAS号：872365-14-5 常用中文名：2-(2-甲基-1-(4-(甲基磺酰基)-2-(三氟甲基)苄基)-1H-吡咯并[2,3-b]吡啶-3-基)乙酸 常用英文名：Fevipiprant 分子式：C19H17F3N2O4S 分子量：426.409 密度：1.4±0.1 g/cm3 沸点：637.6±55.0 °C at 760 mmHg 熔点：N/A 闪点：339.4±31.5 °C 储存条件：2-8°C，干燥密封 |
- 上海化源世纪贸易有限公司
- 上海市 上海市 普陀区
- 产品名：Fevipiprant
- 价格：
- 纯度：99.0%
- 备货期：10天
- 联系人：徐经理
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2-(2-甲基-1-(4-(甲基磺酰基)-2-(三氟甲基)苄基)-1H-吡咯并[2,3-b]吡啶-3-基)乙酸生产厂家
参考价格：$79/10mM*1mLinDMSO