3-(2,4-DIMETHOXYBENZYL)-3,4,5,6-TETRAHYDRO-2,3'-BIPYRIDINE
更新时间：2022-02-12 13:30:36
采购访问：39次
| 常用名 | GTS-21二盐酸盐(DMBX-A) | CAS号 | 156223-05-1 |
|---|---|---|---|
| 价格 | $需询单/100g $需询单/1kg $需询单/100kg $需询单/1000kg | 纯度 | 98.0% |
| 备货期 | 需询单 | 库存 | 询单 |
| 产品详情（用途，包装等）
用途： GTS-21 dihydrochloride is a selective α7 nicotinic acetylcholine receptor agonist, has recently been established as a promising treatment for inflammation. Target: nAChRin vitro: GTS-21 is one of the most potent α7nAChR agonists, has been reported to attenuate pro-inflammatory cytokine production, improve outcomes in sepsis models, pancreatitis, and ischemia-reperfusion injury, and inhibit the production of endotoxin-induced TNF in lung tissue. In addition, recent studies have demonstrated that GTS-21 inhibits the activities of endothelial cells and monocyte macrophages, as well as the secretion of pro-inflammatory cytokines in peripheral blood samples, by regulating the JAK2-STAT3 pathway. [1] in vivo: In septic animals, GTS-21 significantly ameliorated GI motility, lowered systemic and colonic levels of IL-6, decreased colonic permeability, and decreased the number of positive cultures obtained from blood and mesenteric lymph nodes. Splenectomy prevented animals from developing sepsis-induced ileus. Chrna7 mice displayed a more severe septic phenotype, whereas GTS-21 remarkably was also beneficial in these animals. [2] 物理化学性质： CAS号：156223-05-1 常用中文名：GTS-21二盐酸盐(DMBX-A) 常用英文名：GTS-21 分子式：C19H22Cl2N2O2 分子量：381.30 密度：1.1±0.1 g/cm3 沸点：485.6±45.0 °C at 760 mmHg 熔点：216-217℃ (decomposition) 闪点：247.5±28.7 °C 储存条件：2-8°C |
达阳化工（杭州）有限公司
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地址：浙江省杭州市西湖区文三路259号2栋9楼
地区： 浙江省 杭州市 西湖区
联系人：王小姐
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主要市场：Mainly in Southeast Asia and European and American markets
年贸易额：10 to 20 million USD
外贸占销售比例：90%
主要合作伙伴：
- 上海阿拉丁生化科技股份有限公司
- 上海市 上海市 浦东新区
- 产品名：GTS-21二盐酸盐（DMBX-A）
- 价格： ￥407.9/5mg ￥1960.9/100mg ￥581.9/10mg ￥1162.9/25mg
- 纯度：98.0%
- 备货期：1天
- 联系人：阿拉丁
- 上海化源世纪贸易有限公司
- 上海市 上海市 普陀区
- 产品名：(E)-3-(2,4-二甲氧基苯基)亚甲基)-3,4,5,6-四氢-2,3'-联吡啶二盐酸盐
- 价格：
- 纯度：99.0%
- 备货期：10天
- 联系人：徐经理
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参考价格：$66/10mM*1mLinDMSO