| 常用名 | (R)-4-(叔丁基)-N-(6-(2,3-二羟基丙氧基)-5-(2-甲氧基苯氧基)-2-(4-甲氧基苯基)嘧啶-4-基)苯磺酰胺 | CAS号 | 175556-12-4 |
|---|---|---|---|
| 价格 | $2450.0/1g $650.0/100mg $1200.0/250mg | 纯度 | 98.0% |
| 备货期 | 3天 | 库存 | 3 |
| 产品网页 | https://www.dcchemicals.com/product_show-RO_46-8443.html | ||
| 产品详情(用途,包装等)
RO 46-8443 is the first non-peptide endothelin ETB receptor selective antagonist. RO 46-8443 displays up to 2000-fold selectivity for ETB receptors both in terms of binding inhibitory potency and functional inhibition. The observed parallel rightward shift of concentration-response curves with different antagonist concentrations is consistent with a competitive binding mode. Since R0 46-8443 selectively inhibits ETB receptor mediated responses, it is a valuable tool for clarifying the role of ETB receptors in pathology. |