GSK864
更新时间：2024-07-17 15:06:38
采购访问：12次
| 常用名 | GSK864 | CAS号 | 1816331-66-4 |
|---|---|---|---|
| 价格 | $700.0/100mg $1300.0/250mg $2600.0/1g | 纯度 | 98.0% |
| 备货期 | 3天 | 库存 | 3 |
| 产品网页 | https://www.dcchemicals.com/product_show-GSK864.html | ||
| 产品详情（用途，包装等）
GSK864 is a potent and selective inhibitor of mutant IDH1. GSK864 inhibits IDH1 mutants R132C/R132H/R132G with IC50 values of 9/15/17 nM, respectively, and is moderately selective over wild-type IDH1 and IDH2 mutants/wild-type. Treatment of R132C IDH1 mutant HT-1080 cells for 24 hours with GSK864 results in a dose-dependent reduction of 2-hydroxyglutarate (2-HG), which is not observed with GSK990, a structurally similar compound which is inactive as an IDH1 inhibitor. GSK864 has been shown to be selective in vitro for IDH1 over other classes of proteins (7TMs, ion channels, kinases) and chemoproteomic studies with GSK321, an analog of GSK864, confirm selective binding of IDH1 by this chemical series. GSK864 has a pharmacokinetic profile suitable for in vivo studies. |
DC Chemicals Limited
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主要市场：
年贸易额：>1000万
外贸占销售比例：
主要合作伙伴：
- 上海化源生化科技有限公司
- 上海市 上海市 普陀区
- 产品名：GSK864
- 价格：
- 纯度：99.0%
- 备货期：10天
- 联系人：徐经理
- 上海源溪生物科技有限公司
- 上海市 上海市 浦东新区
- 产品名：GSK864
- 价格： ￥需询单/1g
- 纯度：98.9%
- 备货期：1天
- 联系人：赖经理
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参考价格：￥2396/10 mM * 1 mL in DMSO