5'-脱氧-5-氟尿苷
更新时间：2024-06-29 22:08:15
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| 常用名 | 去氧氟尿苷 | CAS号 | 3094-09-5 |
|---|---|---|---|
| 价格 | ￥118.0/1g ￥348.0/5g | 纯度 | 98.0% |
| 备货期 | 2天 | 库存 | 询单 |
| 产品详情（用途，包装等）
用途： Doxifluridine(Ro 21-9738; 5'-DFUR) is a thymidine phosphorylase activator for PC9-DPE2 cells with IC50 of 0.62 μM. IC50 value: 0.62 μM(PC9-DPE2 cell).Target: Nucleoside antimetabolite/analogDoxifluridine is a fluoropyrimidine derivative and oral prodrug of the antineoplastic agent 5-fluorouracil (5-FU) with antitumor activity. Doxifluridine, designed to circumvent the rapid degradation of 5-FU by dihydropyrimidine dehydrogenase in the gut wall, is converted into 5-FU in the presence of pyrimidine nucleoside phosphorylase. 5-FU interferes with DNA synthesis and subsequent cell division by reducing normal thymidine production and interferes with RNA transcription by competing with uridine triphosphate for incorporation into the RNA strand.in vitro: 5'-DFUR's metabolic product(N3-Me-5'-dFUR) was found to be non-toxic in all the cell growth experiments performed. The absence of cytotoxicity could be explained by the observation that the metabolite was not recognized as a substrate by thymidine phosphorilase, the enzyme responsible for 5-fluorouracil (5-FU) release from doxifluridine, as ascertained by high-performance liquid chromatography/ultraviolet (HPLC-UV) analysis of the incubation mixture[1].in vivo: Administration of 200 mg of Furtulon to 23 beagle dogs, the plasma concentrations of doxifluridine, 5-FU, and 5-FUrd were measured simultaneously, using LC-MS/MS. The parent-metabolite compartment model with first-order absorption and Michaelis-Menten kinetics described the pharmacokinetics of doxifluridine, 5-FU, and 5-FUrd. Michaelis-Menten kinetics sufficiently explained the generation and elimination processes of 5-FU and 5-FUrd[2].Clinical trial: A phase II study of doxifluridine and docetaxel combination chemotherapy for advanced or recurrent gastric cancer was reported in 2009[3]. 物理化学性质： CAS号：3094-09-5 常用中文名：去氧氟尿苷 常用英文名：Doxifluridine 分子式：C9H11FN2O5 分子量：246.192 密度：1.6±0.1 g/cm3 沸点：N/A 熔点：188-192 °C(lit.) 闪点：N/A 储存条件：-20°C Freezer |
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- 上海吉至生化科技有限公司
- 上海市 上海市 奉贤区
- 产品名：5'-脱氧-5-氟尿苷
- 价格： ￥118.0/1g ￥348.0/5g
- 纯度：98.0%
- 备货期：2天
- 联系人：刘佳
- 上海源溪生物科技有限公司
- 上海市 上海市 浦东新区
- 产品名：Doxifluridine/5-Fluoro-5′-deoxyuridine
- 价格： ￥需询单/1g
- 纯度：98.9%
- 备货期：1天
- 联系人：赖经理
- 上海脉铂医药科技有限公司
- 上海市 上海市 嘉定区
- 产品名：去氧氟尿苷
- 价格： ￥509.0/1g
- 纯度：98.0%
- 备货期：2天
- 联系人：李先生
- 上海阿拉丁生化科技股份有限公司
- 上海市 上海市 浦东新区
- 产品名：5'-脱氧-5-氟尿苷
- 价格： ￥43.9/1g ￥405.9/1ml ￥2570.9/100g ￥803.9/25g
- 纯度：98.0%
- 备货期：1天
- 联系人：阿拉丁
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参考价格：￥234/5g