Tetrahedron

1, 8-Diazabicyclo [5.4. 0] undec-7-ene (DBU)-promoted efficient and versatile aza-Michael addition

CE Yeom, MJ Kim, BM Kim

文献索引：Yeom, Chang-Eun; Kim, Mi Jeong; Kim, B. Moon Tetrahedron, 2007 , vol. 63, # 4 p. 904 - 909

全文：HTML全文

被引用次数: 106

摘要

A convenient and versatile method was developed for aza-Michael addition using a substoichiometric amount of 1, 8-diazabicyclo [5.4. 0] undec-7-ene (DBU). Various nitrogen nucleophiles were efficiently introduced to α, β-unsaturated carbonyl compounds employing 0.5 equiv of DBU. Furthermore, other heteroatomic nucleophiles could also be introduced successfully under the same reaction conditions.