Abstract Efficient routes for the regioselective synthesis of 3, 5-bis (het) arylisoxazoles with complementary regioselectivity have been developed. The methods involve the cyclocondensation of hydroxylamine hydrochloride with either 1, 3-bis (het) aryl-monothio- substituted 1, 3-diketones 1 or with 3-methylthio-1, 3-bis (het) aryl-2-propenones 2 under various reaction conditions. In the first protocol, diketones 1 were treated with ...
