Organic letters

Efficient and regioselective one-pot synthesis of 3-substituted and 3, 5-disubstituted isoxazoles

S Tang, J He, Y Sun, L He, X She

文献索引：Tang, Shibing; He, Jinmei; Sun, Yongquan; He, Liuer; She, Xuegong Organic Letters, 2009 , vol. 11, # 17 p. 3982 - 3985

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被引用次数: 68

摘要

A series of 3-substituted and 3, 5-disubstituted isoxazoles have been efficiently synthesized in moderate to excellent yields by the reaction of N-hydroxyl-4-toluenesulfonamide with α, β- unsaturated aldehydes/ketones. This novel strategy is associated with readily available starting materials, mild conditions, high regioselectivity, and wide scope.