Journal of the American Chemical Society

Derivatives of Piperazine. XVIII. Synthesis of Substituted Piperazines and the Hydrolysis of Amines

JP Bain, CB Pollard

文献索引：Bain; Pollard Journal of the American Chemical Society, 1939 , vol. 61, p. 2704

被引用次数: 5

摘要

It has been shown that N-phenylpiperazine2 may be prepared readily by heating a mixture of aniline and diethanolamine hydrochlorides. We have found that this method cannot be extended conveniently to the preparation of C-substituted piperazines from arylamines and diisopropanol- amine. We have shown that piperazines may he prepared from amino alcohols3 using the catalytic alkylation methods of Paden and Adkins* and Hill and Adkim6 This ...