Sulfonamides are important functional groups in medicinal chemistry as they have many desirable properties such as their ability to act as H-bond donors and acceptors. They are the basis of some of the early antibiotics such as the sulfanilamides. They are widespread in other classes of pharmaceuticals such as the anti-inflammatory agent celecoxib (1) and sildenafil (2) for erectile dysfunction (Fig. 1). ... Examples of drugs with a sulfonamide functionality. Examples of drugs with a ...
