Tetrahedron Letters

A general and mild two-step procedure for the synthesis of aryl and heteroaryl sulfonamides from the corresponding iodides

DKH Ho, L Chan, A Hooper, PE Brennan

Index: Ho, Danny K.H.; Chan, Lily; Hooper, Alice; Brennan, Paul E. Tetrahedron Letters, 2011 , vol. 52, # 7 p. 820 - 823

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Citation Number: 21

Abstract

Sulfonamides are important functional groups in medicinal chemistry as they have many desirable properties such as their ability to act as H-bond donors and acceptors. They are the basis of some of the early antibiotics such as the sulfanilamides. They are widespread in other classes of pharmaceuticals such as the anti-inflammatory agent celecoxib (1) and sildenafil (2) for erectile dysfunction (Fig. 1). ... Examples of drugs with a sulfonamide functionality. Examples of drugs with a ...