Molecules 2010-06-01

Synthesis of bosutinib from 3-methoxy-4-hydroxybenzoic acid.

Xiao Jia Yin, Guan Hong Xu, Xu Sun, Yan Peng, Xing Ji, Ke Jiang, Fei Li

文献索引：Molecules 15(6) , 4261-6, (2010)

摘要

This paper reports a novel synthesis of bosutinib starting from 3-methoxy-4-hydroxybenzoic acid. The process starts with esterification of the starting material, followed by alkylation, nitration, reduction, cyclization, chlorination and two successive amination reactions. The intermediates and target molecule were characterized by (1)H-NMR, (13)C-NMR, MS and the purities of all the compounds were determined by HPLC.

结构式	名称/CAS号	分子式	全部文献
	氰基乙醛缩二乙醇 CAS:2032-34-0	C₇H₁₃NO₂

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Synthesis of bosutinib from 3-methoxy-4-hydroxybenzoic acid.

摘要

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