Molecules 2010-06-01

Synthesis of bosutinib from 3-methoxy-4-hydroxybenzoic acid.

Xiao Jia Yin, Guan Hong Xu, Xu Sun, Yan Peng, Xing Ji, Ke Jiang, Fei Li

Index: Molecules 15(6) , 4261-6, (2010)

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Abstract

This paper reports a novel synthesis of bosutinib starting from 3-methoxy-4-hydroxybenzoic acid. The process starts with esterification of the starting material, followed by alkylation, nitration, reduction, cyclization, chlorination and two successive amination reactions. The intermediates and target molecule were characterized by (1)H-NMR, (13)C-NMR, MS and the purities of all the compounds were determined by HPLC.

Structure	Name/CAS No.	Molecular Formula	Articles
	3,3-Diethoxypropanenitrile CAS:2032-34-0	C₇H₁₃NO₂

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Synthesis of bosutinib from 3-methoxy-4-hydroxybenzoic acid.

Abstract

Related Compounds