Synthesis of 3′-O-phosphonoethyl nucleosides with an adenine and a thymine base moiety

Q Huang, P Herdewijn

文献索引：Huang, Qiuya; Herdewijn, Piet Nucleosides, Nucleotides and Nucleic Acids, 2009 , vol. 28, # 5-7 p. 337 - 351

全文：HTML全文

被引用次数: 6

摘要

The synthesis and antiviral evaluation of new 3′-O-phosphonoethyl modified phosphonate nucleosides related to PMDTA and PMDTT is described. The reaction scheme starts from protected L-threose and the phosphonate group is introduced by the Arbuzov reaction. The 2′-OH as well as the 2′-deoxygenated nucleosides have been obtained. Unfortunately, none of these synthesized compounds shows activity against HIV and HCV.