Advanced Synthesis & Catalysis

Multiple Organolithium Generation in the Continuous Flow Synthesis of Amitriptyline

L Kupracz, A Kirschning

文献索引：Kupracz, Lukas; Kirschning, Andreas Advanced Synthesis and Catalysis, 2013 , vol. 355, # 17 p. 3375 - 3380

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被引用次数: 33

摘要

Abstract: A continuous flow protocol for the preparation of the tricyclic antidepressant (TCA) amitriptyline is reported. The advantages of flow chemistry when handling organometallic agents as well as when performing reaction with gases are demonstrated. Continuous multilithiation combined with carboxylation and the Parham cyclization, a Grignard addition and thermolytic water elimination by inductive heating are key features of the multistep ...