The total synthesis of dl-6-demethyl-6-deoxytetracycline

JJ Korst, JD Johnston, K Butler, EJ Bianco…

文献索引：Korst,J.J. et al. Journal of the American Chemical Society, 1968 , vol. 90, # 2 p. 439 - 457

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被引用次数: 53

摘要

Abstract: The first total synthesis of the prototypic tetracycline antibiotic, dl-6-demethyl-6- deoxytetracycline (7), from methyl m-methoxybenzoate (lo), is described. nterest in the tetracyclines, a class of uniquely con-I stituted hydronaphthacene derivatives characterized by the intricacy of their chemistry and notable for their utility in medical practice, had its origin in the announcement by Duggar in 1948 of the discovery of Aureomycin [(chlortetracycline ...