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举例 :可输入Filippa Pettersson 或者 Cancer Res. 75(6) , 1102-12, (2015) 或者10.1002/anie.201600521

Tetrahedron

Cycloadditions of nitrile oxides to amidoximes. A general synthesis of 3, 5-disubstituted 1, 2, 4-oxadiazole-4-oxides.

P Quadrelli, AG Invernizzi, M Falzoni, P Caramella

文献索引：Quadrelli, Paolo; Invernizzi, Anna Gamba; Falzoni, Mario; Caramella, Pierluigi Tetrahedron, 1997 , vol. 53, # 5 p. 1787 - 1796

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被引用次数: 27

摘要

The cycloaddition of nitrile oxides to amidoximes is a general method for the sinthesis of 3, 5- disubstituted 1, 2, 4-oxadiazole-4-oxides with the same or different substituents. The yields are only moderate since an equivalent amount of the nitrile oxide is consumed by reaction with the amine released in the fragmentation of the primary cycloadducts and reforms the amidoxime. With excess nitrile oxides the 1, 2, 4-oxadiazole-4-oxides undergo a ...

邻氯苯甲醛肟结构式

邻氯苯甲醛肟

~%

3,5-二苯基-1,2,4-噁二唑结构式

3,5-二苯基-1,2,4-噁二唑

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4-oxido-3,5-diphenyl-1,2,4-oxadiazol-4-ium结构式

4-oxido-3,5-dip...

~61%

3,5-二苯基-1,2,4-噁二唑结构式

3,5-二苯基-1,2,4-噁二唑

未登录结构式

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9,10-二甲基蒽结构式

9,10-二甲基蒽

N-Phenylbenzohydroxamic acid结构式

N-Phenylbenzohy...

~62%

3,5-二苯基-1,2,4-噁二唑结构式

3,5-二苯基-1,2,4-噁二唑

未登录结构式

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9,10-二甲基蒽结构式

9,10-二甲基蒽

potassium salt of 2,2-dicyano-N-methylacetamide结构式

potassium salt ...

~59%

3,5-二苯基-1,2,4-噁二唑结构式

3,5-二苯基-1,2,4-噁二唑

N-(4-chlorobenzoyl)-9,10-dihydro-9,10-dimethyl-9,10-epoxyiminoanthracene结构式

N-(4-chlorobenz...

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N-Phenylbenzohydroxamic acid结构式

N-Phenylbenzohy...

4-(N-hydroxy-benzimidoyl)-morpholine结构式

4-(N-hydroxy-be...

~%

3,5-二苯基-1,2,4-噁二唑结构式

3,5-二苯基-1,2,4-噁二唑

4-oxido-3,5-diphenyl-1,2,4-oxadiazol-4-ium结构式

4-oxido-3,5-dip...

详细查看详情

N-Phenylbenzohydroxamic acid结构式

N-Phenylbenzohy...

~%

3,5-二苯基-1,2,4-噁二唑结构式

3,5-二苯基-1,2,4-噁二唑

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(E)-N,N-Dimethylbenzamid-oxim结构式

(E)-N,N-Dimethy...

~%

3,5-二苯基-1,2,4-噁二唑结构式

3,5-二苯基-1,2,4-噁二唑

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Benzenecarboximidamide,N-hydroxy-N'-methyl结构式

Benzenecarboxim...

~%

3,5-二苯基-1,2,4-噁二唑结构式

3,5-二苯基-1,2,4-噁二唑

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N-hydroxy-4-methyl-benzenecarboximidoyl chloride结构式

N-hydroxy-4-met...

~%

3,5-二苯基-1,2,4-噁二唑结构式

3,5-二苯基-1,2,4-噁二唑

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N-羟基-4-硝基亚胺苄基氯化物结构式

N-羟基-4-硝基亚胺苄基氯化物

~%

3,5-二苯基-1,2,4-噁二唑结构式

3,5-二苯基-1,2,4-噁二唑

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未登录结构式

~%

3,5-二苯基-1,2,4-噁二唑结构式

3,5-二苯基-1,2,4-噁二唑

查看详情

(E)-4-chloro-N,N-diethyl-N'-hydroxybenzimidamide结构式

(E)-4-chloro-N,...

~%

3,5-二苯基-1,2,4-噁二唑结构式

3,5-二苯基-1,2,4-噁二唑

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(E)-N,N-diethyl-N'-hydroxy-4-methoxybenzimidamide结构式

(E)-N,N-diethyl...

~%

3,5-二苯基-1,2,4-噁二唑结构式

3,5-二苯基-1,2,4-噁二唑

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(E)-N,N-diethyl-N'-hydroxy-4-nitrobenzimidamide结构式

(E)-N,N-diethyl...

~%

3,5-二苯基-1,2,4-噁二唑结构式

3,5-二苯基-1,2,4-噁二唑

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alpha,4-二氯苯甲醛肟结构式

alpha,4-二氯苯甲醛肟

~%

3,5-二苯基-1,2,4-噁二唑结构式

3,5-二苯基-1,2,4-噁二唑

查看详情

ALPHA-氯-4-甲氧基苯甲醛肟结构式

ALPHA-氯-4-甲氧基苯甲醛肟

~%

3,5-二苯基-1,2,4-噁二唑结构式

3,5-二苯基-1,2,4-噁二唑

查看详情

5-(4-chlorophenyl)-3-methyl-1,2,4-oxadiazole 4-oxide结构式

5-(4-chlorophen...

~%

5-(4-chlorophenyl)-3-methyl-1,2,4-oxadiazole结构式

5-(4-chlorophen...

查看详情

(E)-4-chloro-N,N-diethyl-N'-hydroxybenzimidamide结构式

(E)-4-chloro-N,...

~%

5-(4-chlorophenyl)-3-methyl-1,2,4-oxadiazole结构式

5-(4-chlorophen...

查看详情

alpha,4-二氯苯甲醛肟结构式

alpha,4-二氯苯甲醛肟

~%

5-(4-chlorophenyl)-3-methyl-1,2,4-oxadiazole结构式

5-(4-chlorophen...

查看详情

N,N-diethylamino benzamidoxime结构式

N,N-diethylamin...

N-Phenylbenzohydroxamic acid结构式

N-Phenylbenzohy...

~0%

3,5-二苯基-1,2,4-噁二唑结构式

3,5-二苯基-1,2,4-噁二唑

4-oxido-3,5-diphenyl-1,2,4-oxadiazol-4-ium结构式

4-oxido-3,5-dip...

详细查看详情

benzonitrile oxide结构式

benzonitrile oxide

N,N-diethylamino benzamidoxime结构式

N,N-diethylamin...

~%

3,5-二苯基-1,2,4-噁二唑结构式

3,5-二苯基-1,2,4-噁二唑

4-oxido-3,5-diphenyl-1,2,4-oxadiazol-4-ium结构式

4-oxido-3,5-dip...

详细查看详情

3-phenyl-5-p-tolyl-1,2,4-oxadiazole-4-oxide结构式

3-phenyl-5-p-to...

~%

5-(4-methylphenyl)-3-phenyl-1,2,4-oxadiazole结构式

5-(4-methylphen...

查看详情

N-hydroxy-4-methyl-benzenecarboximidoyl chloride结构式

N-hydroxy-4-met...

~%

5-(4-methylphenyl)-3-phenyl-1,2,4-oxadiazole结构式

5-(4-methylphen...

查看详情

N-Phenylbenzohydroxamic acid结构式

N-Phenylbenzohy...

~%

5-(4-methylphenyl)-3-phenyl-1,2,4-oxadiazole结构式

5-(4-methylphen...

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未登录结构式

~%

5-(4-methylphenyl)-3-phenyl-1,2,4-oxadiazole结构式

5-(4-methylphen...

查看详情

N-Phenylbenzohydroxamic acid结构式

N-Phenylbenzohy...

4-(N-hydroxy-benzimidoyl)-morpholine结构式

4-(N-hydroxy-be...

~%

3,5-二苯基-1,2,4-噁二唑结构式

3,5-二苯基-1,2,4-噁二唑

4-oxido-3,5-diphenyl-1,2,4-oxadiazol-4-ium结构式

4-oxido-3,5-dip...

详细查看详情

N-Phenylbenzohydroxamic acid结构式

N-Phenylbenzohy...

~0%

4-oxido-3,5-diphenyl-1,2,4-oxadiazol-4-ium结构式

4-oxido-3,5-dip...

3-phenyl-5-p-tolyl-1,2,4-oxadiazole-4-oxide结构式

3-phenyl-5-p-to...

查看详情

N-Phenylbenzohydroxamic acid结构式

N-Phenylbenzohy...

未登录结构式

~0%

4-oxido-3,5-diphenyl-1,2,4-oxadiazol-4-ium结构式

4-oxido-3,5-dip...

3-phenyl-5-p-tolyl-1,2,4-oxadiazole-4-oxide结构式

3-phenyl-5-p-to...

查看详情

N-Phenylbenzohydroxamic acid结构式

N-Phenylbenzohy...

(E)-4-chloro-N,N-diethyl-N'-hydroxybenzimidamide结构式

(E)-4-chloro-N,...

~0%

4-oxido-3,5-diphenyl-1,2,4-oxadiazol-4-ium结构式

4-oxido-3,5-dip...

未登录结构式

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N-Phenylbenzohydroxamic acid结构式

N-Phenylbenzohy...

(E)-N,N-diethyl-N'-hydroxy-4-methoxybenzimidamide结构式

(E)-N,N-diethyl...

~0%

4-oxido-3,5-diphenyl-1,2,4-oxadiazol-4-ium结构式

4-oxido-3,5-dip...

未登录结构式

查看详情

N-hydroxy-4-methyl-benzenecarboximidoyl chloride结构式

N-hydroxy-4-met...

~%

4-oxido-3,5-diphenyl-1,2,4-oxadiazol-4-ium结构式

4-oxido-3,5-dip...

查看详情

N-羟基-4-硝基亚胺苄基氯化物结构式

N-羟基-4-硝基亚胺苄基氯化物

~%

4-oxido-3,5-diphenyl-1,2,4-oxadiazol-4-ium结构式

4-oxido-3,5-dip...

查看详情

N-Phenylbenzohydroxamic acid结构式

N-Phenylbenzohy...

~%

4-oxido-3,5-diphenyl-1,2,4-oxadiazol-4-ium结构式

4-oxido-3,5-dip...

查看详情

alpha,4-二氯苯甲醛肟结构式

alpha,4-二氯苯甲醛肟

~%

4-oxido-3,5-diphenyl-1,2,4-oxadiazol-4-ium结构式

4-oxido-3,5-dip...

查看详情

ALPHA-氯-4-甲氧基苯甲醛肟结构式

ALPHA-氯-4-甲氧基苯甲醛肟

~%

4-oxido-3,5-diphenyl-1,2,4-oxadiazol-4-ium结构式

4-oxido-3,5-dip...

查看详情

(E)-N,N-Dimethylbenzamid-oxim结构式

(E)-N,N-Dimethy...

N-Phenylbenzohydroxamic acid结构式

N-Phenylbenzohy...

~%

4-oxido-3,5-diphenyl-1,2,4-oxadiazol-4-ium结构式

4-oxido-3,5-dip...

查看详情

苄胺肟结构式

N-Phenylbenzohydroxamic acid结构式

N-Phenylbenzohy...

~%

4-oxido-3,5-diphenyl-1,2,4-oxadiazol-4-ium结构式

4-oxido-3,5-dip...

查看详情

Benzenecarboximidamide,N-hydroxy-N'-methyl结构式

Benzenecarboxim...

N-Phenylbenzohydroxamic acid结构式

N-Phenylbenzohy...

~%

4-oxido-3,5-diphenyl-1,2,4-oxadiazol-4-ium结构式

4-oxido-3,5-dip...

查看详情

N,N-diethylamino benzamidoxime结构式

N,N-diethylamin...

N-Phenylbenzohydroxamic acid结构式

N-Phenylbenzohy...

~43%

3,5-二苯基-1,2,4-噁二唑结构式

3,5-二苯基-1,2,4-噁二唑

4-oxido-3,5-diphenyl-1,2,4-oxadiazol-4-ium结构式

4-oxido-3,5-dip...

详细查看详情

benzonitrile oxide结构式

benzonitrile oxide

N,N-diethylamino benzamidoxime结构式

N,N-diethylamin...

~%

3,5-二苯基-1,2,4-噁二唑结构式

3,5-二苯基-1,2,4-噁二唑

4-oxido-3,5-diphenyl-1,2,4-oxadiazol-4-ium结构式

4-oxido-3,5-dip...

详细查看详情

氨基甲烷结构式

N-Phenylbenzohydroxamic acid结构式

N-Phenylbenzohy...

~0%

Benzenecarboximidamide,N-hydroxy-N'-methyl结构式

Benzenecarboxim...

一甲胺盐酸盐结构式

一甲胺盐酸盐

查看详情

氨基甲烷结构式

N-Phenylbenzohydroxamic acid结构式

N-Phenylbenzohy...

~77%

Benzenecarboximidamide,N-hydroxy-N'-methyl结构式

Benzenecarboxim...

一甲胺盐酸盐结构式

一甲胺盐酸盐

查看详情

N-Phenylbenzohydroxamic acid结构式

N-Phenylbenzohy...

4-(N-hydroxy-benzimidoyl)-morpholine结构式

4-(N-hydroxy-be...

~%

3,5-二苯基-1,2,4-噁二唑结构式

3,5-二苯基-1,2,4-噁二唑

4-oxido-3,5-diphenyl-1,2,4-oxadiazol-4-ium结构式

4-oxido-3,5-dip...

详细查看详情

N,N-diethylamino benzamidoxime结构式

N,N-diethylamin...

N-Phenylbenzohydroxamic acid结构式

N-Phenylbenzohy...

~0%

3,5-二苯基-1,2,4-噁二唑结构式

3,5-二苯基-1,2,4-噁二唑

4-oxido-3,5-diphenyl-1,2,4-oxadiazol-4-ium结构式

4-oxido-3,5-dip...

详细查看详情

benzonitrile oxide结构式

benzonitrile oxide

N,N-diethylamino benzamidoxime结构式

N,N-diethylamin...

~%

3,5-二苯基-1,2,4-噁二唑结构式

3,5-二苯基-1,2,4-噁二唑

4-oxido-3,5-diphenyl-1,2,4-oxadiazol-4-ium结构式

4-oxido-3,5-dip...

详细查看详情

N-hydroxy-4-methyl-benzenecarboximidoyl chloride结构式

N-hydroxy-4-met...

~%

3,5-bis(4-methylphenyl)-4-oxido-1,2,4-oxadiazol-4-ium结构式

3,5-bis(4-methy...

查看详情

(E)-N,N-diethyl-N'-hydroxy-4-nitrobenzimidamide结构式

(E)-N,N-diethyl...

未登录结构式

~27%

3,5-bis(4-nitrophenyl)-4-oxido-1,2,4-oxadiazol-4-ium结构式

3,5-bis(4-nitro...

查看详情

未登录结构式

~0%

3,5-bis(4-nitrophenyl)-4-oxido-1,2,4-oxadiazol-4-ium结构式

3,5-bis(4-nitro...

未登录结构式

查看详情

N,N-diethylamino benzamidoxime结构式

N,N-diethylamin...

未登录结构式

~0%

3,5-bis(4-nitrophenyl)-4-oxido-1,2,4-oxadiazol-4-ium结构式

3,5-bis(4-nitro...

未登录结构式

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N-羟基-4-硝基亚胺苄基氯化物结构式

N-羟基-4-硝基亚胺苄基氯化物

~%

3,5-bis(4-nitrophenyl)-4-oxido-1,2,4-oxadiazol-4-ium结构式

3,5-bis(4-nitro...

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(E)-4-chloro-N,N-diethyl-N'-hydroxybenzimidamide结构式

(E)-4-chloro-N,...

potassium salt of 2,2-dicyano-N-methylacetamide结构式

potassium salt ...

~33%

3,5-bis(4-chlorophenyl)-4-oxido-1,2,4-oxadiazol-4-ium结构式

3,5-bis(4-chlor...

查看详情

potassium salt of 2,2-dicyano-N-methylacetamide结构式

potassium salt ...

~0%

3,5-bis(4-chlorophenyl)-4-oxido-1,2,4-oxadiazol-4-ium结构式

3,5-bis(4-chlor...

3-(4-chlorophenyl)-5-phenyl-1,2,4-oxadiazole 4-oxide结构式

3-(4-chlorophen...

查看详情

N,N-diethylamino benzamidoxime结构式

N,N-diethylamin...

potassium salt of 2,2-dicyano-N-methylacetamide结构式

potassium salt ...

~0%

3,5-bis(4-chlorophenyl)-4-oxido-1,2,4-oxadiazol-4-ium结构式

3,5-bis(4-chlor...

3-(4-chlorophenyl)-5-phenyl-1,2,4-oxadiazole 4-oxide结构式

3-(4-chlorophen...

查看详情

吗啉结构式

邻氯苯甲醛肟结构式

邻氯苯甲醛肟

~0%

吗啡啉盐酸盐结构式

吗啡啉盐酸盐

4-(N-hydroxy-benzimidoyl)-morpholine结构式

4-(N-hydroxy-be...

查看详情

5-phenyl-3-p-tolyl-1,2,4-oxadiasole-4-oxide结构式

5-phenyl-3-p-to...

~%

3-(4-methylphenyl)-5-phenyl-1,2,4-oxadiazole结构式

3-(4-methylphen...

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A novel synthesis of 1, 2, 4-oxadiazoles and isoxazoles

[Kivrak, Arif; Zora, Metin Tetrahedron, 2014 , vol. 70, # 4 p. 817 - 831]

A novel synthesis of 1, 2, 4-oxadiazoles and isoxazoles

[Kivrak, Arif; Zora, Metin Tetrahedron, 2014 , vol. 70, # 4 p. 817 - 831]

Hypervalent iodine catalyzed generation of nitrile oxides fr...

[Yoshimura, Akira; Middleton, Kyle R.; Todora, Anthony D.; Kastern, Brent J.; Koski, Steven R.; Maskaev, Andrey V.; Zhdankin, Viktor V. Organic Letters, 2013 , vol. 15, # 15 p. 4010 - 4013]

Orthogonal aerobic conversion of N-benzyl amidoximes to 1, 2...

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Sulfate Radical Anion (SO4•–) Mediated C (sp3)–H Nitrogenati...

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