Tetrahedron

A novel synthesis of 1, 2, 4-oxadiazoles and isoxazoles

A Kivrak, M Zora

文献索引：Kivrak, Arif; Zora, Metin Tetrahedron, 2014 , vol. 70, # 4 p. 817 - 831

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被引用次数: 13

摘要

Abstract A novel synthesis of 1, 2, 4-oxadiazoles and isoxazoles is described by utilizing the reactions between amidoximes and α, β-alkynic aldehydes and/or ketones. Conjugate addition products, obtained from amidoximes and α, β-alkynic aldehydes and/or ketones, afford 1, 2, 4-oxadiazoles and isoxazoles when treated with bases and acids, respectively. 1, 2, 4-Oxadiazoles can also be synthesized directly from amidoximes and α, β-alkynic ...