Bioscience, Biotechnology, and Biochemistry 2007-10-01

Identification and determination of alpha-dicarbonyl compounds formed in the degradation of sugars.

Teruyuki Usui, Satoshi Yanagisawa, Mio Ohguchi, Miku Yoshino, Risa Kawabata, Junko Kishimoto, Yumi Arai, Kaoru Aida, Hirohito Watanabe, Fumitaka Hayase

文献索引：Biosci. Biotechnol. Biochem. 71(10) , 2465-72, (2007)

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摘要

The alpha-dicarbonyl compounds formed in the degradation of glucose and fructose were analyzed by HPLC using 2,3-diaminonaphthalene as derivatizing reagent, and identified as glucosone (GLUCO), 3-deoxyglucosone (3DG), 3-deoxyxylosone (3DX), tetrosone (TSO), triosone (TRIO), 3-deoxytetrosone (3DT), glyoxal (GO), and methylglyoxal (MGO). The results suggest that alpha-dicarbonyl compounds were formed from glucose via non-oxidative 3-deoxyglucosone formation and oxidative glucosone formation in glucose degradation. In addition, TRIO, GO, and MGO were also formed from glyceraldehyde as intermediate. The alpha-dicarbonyl compounds might be formed from glucose via these pathways in diabetes.