Benzylated 1, 2, 3-triazoles as anticoccidiostats

…, JE Brown, DW Graham, FS Waksmunski

文献索引：Bochis; Chabala; Harris; Peterson; Barash; Beattie; Brown; Graham; Waksmunski; Tischler; Joshua; Smith; Colwell; Wyvratt Jr.; Fisher; Tamas; Nicolich; Schleim; Wilks et al. Journal of Medicinal Chemistry, 1991 , vol. 34, # 9 p. 2843 - 2852

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被引用次数: 27

摘要

Substituted 5-amino-4-carbamoyl-1, 2, 3-triazoles 3a-w were prepared by two synthetic schemes and evaluated in vivo for anticoccidial activity. Both schemes proceeded by brominating appropriately substituted toluenes 4a-s, v to Sa-s, v. In Scheme I, the brominated benzyl analogues 5 were converted to the corresponding benzyl azides 6, which were treated with cyanoacetamide to yield 1-substituted-5-amino-4-carbamoyl-l, 2, 3- ...