9-Acridinylguanidines. Mono-, bis-, tris-, and tetrakis-9-acridinyl derivatives of guanidine connected via polymethylene linkers

JB Hansen, T Thomsen, O Buchardt

文献索引：Hansen, John B.; Thomsen, Tove; Buchardt, Ole Journal of the Chemical Society, Chemical Communications, 1983 , # 18 p. 1015 - 1016

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被引用次数: 2

摘要

9-(Aminoa1kyl)aminoacridines exhibit a variety of biological effects, and are pharmacologically important as antiparasitic and cytostatic agents.l They bind to double stranded DNA by intercalation in such a way that the 9-amino group appears to be in the direction of the DNA minor groove.2 The strength of this binding2 and the DNA site specificity are influenced by electrostatic interactions and hydrogen bonds between the substituents on the 9-amino group of the ...