9-Acridinylguanidines. Mono-, bis-, tris-, and tetrakis-9-acridinyl derivatives of guanidine connected via polymethylene linkers

JB Hansen, T Thomsen, O Buchardt

Index: Hansen, John B.; Thomsen, Tove; Buchardt, Ole Journal of the Chemical Society, Chemical Communications, 1983 , # 18 p. 1015 - 1016

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Citation Number: 2

Abstract

9-(Aminoa1kyl)aminoacridines exhibit a variety of biological effects, and are pharmacologically important as antiparasitic and cytostatic agents.l They bind to double stranded DNA by intercalation in such a way that the 9-amino group appears to be in the direction of the DNA minor groove.2 The strength of this binding2 and the DNA site specificity are influenced by electrostatic interactions and hydrogen bonds between the substituents on the 9-amino group of the ...