Journal of Organic Chemistry 2008-09-05

Me3SiCl-promoted three-component coupling reaction of a functionalized enamine, an acetal, and an alkyne: an unprecedented approach to the synthesis of tetrasubstituted pyridines via a [3 + 2 + 1] intermolecular cyclization.

Toshiaki Sasada, Norio Sakai, Takeo Konakahara

文献索引：J. Org. Chem. 73(17) , 6905-8, (2008)

摘要

We have identified a Me3SiCl-mediated three-component coupling reaction of a functionalized enamine, N,N-dimethylformamide diethyl acetal, and an internal alkyne having an electron-withdrawing group that produces 2,3,4,5-tetrasubstituted pyridine derivatives in good to excellent yields via a single-step reaction.

结构式	名称/CAS号	分子式	全部文献
	N,N-二甲基甲酰胺二乙基缩醛 CAS:1188-33-6	C₇H₁₇NO₂

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Me3SiCl-promoted three-component coupling reaction of a functionalized enamine, an acetal, and an alkyne: an unprecedented approach to the synthesis of tetrasubstituted pyridines via a [3 + 2 + 1] intermolecular cyclization.

摘要

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