Journal of Organic Chemistry 2008-09-05

Me3SiCl-promoted three-component coupling reaction of a functionalized enamine, an acetal, and an alkyne: an unprecedented approach to the synthesis of tetrasubstituted pyridines via a [3 + 2 + 1] intermolecular cyclization.

Toshiaki Sasada, Norio Sakai, Takeo Konakahara

Index: J. Org. Chem. 73(17) , 6905-8, (2008)

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Abstract

We have identified a Me3SiCl-mediated three-component coupling reaction of a functionalized enamine, N,N-dimethylformamide diethyl acetal, and an internal alkyne having an electron-withdrawing group that produces 2,3,4,5-tetrasubstituted pyridine derivatives in good to excellent yields via a single-step reaction.

Structure	Name/CAS No.	Molecular Formula	Articles
	1,1-Diethoxy-N,N-dimethylmethanamine CAS:1188-33-6	C₇H₁₇NO₂

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Me3SiCl-promoted three-component coupling reaction of a functionalized enamine, an acetal, and an alkyne: an unprecedented approach to the synthesis of tetrasubstituted pyridines via a [3 + 2 + 1] intermolecular cyclization.

Abstract

Related Compounds