New trypanocidal hybrid compounds from the association of hydrazone moieties and benzofuroxan heterocycle

…, A Chidichimo, JJ Cazzulo, C Olea-Azar…

文献索引：Porcal, Williams; Hernandez, Paola; Boiani, Lucia; Boiani, Mariana; Ferreira, Ana; Chidichimo, Agustina; Cazzulo, Juan J.; Olea-Azar, Claudio; Gonzalez, Mercedes; Cerecetto, Hugo Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 14 p. 6995 - 7004

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被引用次数: 41

摘要

Hybrid compounds containing hydrazones and benzofuroxan pharmacophores were designed as potential Trypanosoma cruzi-enzyme inhibitors. The majority of the designed compounds was successfully synthesized and biologically evaluated displaying remarkable in vitro activity against different strains of T. cruzi. Unspecific cytotoxicity was evaluated using mouse macrophages, displaying isothiosemicarbazone 10 and thiosemicarbazone 12 ...