Organic Letters 2013-06-21

A practical method for the synthesis of highly enantioenriched trans-1,2-amino alcohols.

James A Birrell, Eric N Jacobsen

文献索引：Org. Lett. 15(12) , 2895-7, (2013)

全文：HTML全文

摘要

A highly enantioselective addition of phenyl carbamate to meso-epoxides has been developed to efficiently generate protected trans-1,2-amino alcohols. This transformation is promoted by an oligomeric (salen)Co-OTf catalyst and has been used to prepare two useful 2-aminocycloalkanol hydrochlorides in enantiopure form on a multigram scale from commercially available starting materials.