Synlett

Di-tert-butylmagnesium as an atom-efficient, carbon-centred base reagent for the preparation of silyl enol ethers from ketones

WJ Kerr, AJB Watson, D Hayes

文献索引：Kerr, William J.; Watson, Allan J. B.; Hayes, Douglas Synlett, 2008 , # 9 p. 1386 - 1390

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被引用次数: 3

摘要

Abstract Di-tert-butylmagnesium has been found to be a reactive, yet non-nucleophilic and non-reductive, carbon-centred base for the deprotonation of a series of ketones. This reagent demonstrates equally high reactivity when used as either the pre-formed reagent, or in a more accessible one-pot protocol from the parent Grignard reagent, and offers improved atom-efficiency over more traditionally employed bases.