Photochemical electrocyclisation of 3-vinylindoles to pyrido [2, 3-a]-, pyrido [4, 3-a]-and thieno [2, 3-a]-carbazoles: design, synthesis, DNA binding and antitumor cell …

…, S Depauw, C Dassi, MH David-Cordonnier

文献索引：Lemster, Thomas; Pindur, Ulf; Lenglet, Gaelle; Depauw, Sabine; Dassi, Christelle; David-Cordonnier, Marie-Helene European Journal of Medicinal Chemistry, 2009 , vol. 44, # 8 p. 3235 - 3252

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被引用次数: 43

摘要

In the context of the design and synthesis of DNA ligands, some new hetarene annelated carbazoles were synthesized. As lead structure the intercalating tetracyclic systems pyrido [2, 3-a]-and pyrido [4, 3-a]-carbazoles and in one case a thieno [2, 3-a]-carbazole were taken into account. A dialkyl amino amidic chain was introduced to the planar chromophoric system with the intent to generate minor groove binding properties. The cytotoxicity of ...