The synthesis of neurotensin antagonist SR 48692 for prostate cancer research

IR Baxendale, S Cheung, MO Kitching, SV Ley…

文献索引：Baxendale; Cheung; Kitching; Ley; Shearman Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 14 p. 4378 - 4387

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被引用次数: 8

摘要

An improved synthesis of the molecule SR 48692 is presented and its use as a neurotensin antagonist biological probe for use in cancer research is described. The preparation includes an number of enhanced chemical conversions and strategies to overcome some of the limiting synthetic transformations in the original chemical route.