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Journal of Organic Chemistry 2006-03-17

Mild organocatalytic alpha-methylenation of aldehydes.

Anniina Erkkilä, Petri M Pihko

文献索引:J. Org. Chem. 71 , 2538, (2006)

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摘要

A rapid and extremely convenient method for alpha-methylenation of aldehydes with aqueous formaldehyde is described. Two optimal catalytic systems are presented that allow short reaction times and afford the functionalized products in good to excellent yields (up to 99%) and chemoselectivity.

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