Tetrahedron letters

Microwave-assisted synthesis of α-hydroxy ketone and α-diketone and pyrazine derivatives from α-halo and α, α′-dibromo ketone

T Utsukihara, H Nakamura, M Watanabe, CA Horiuchi

文献索引：Utsukihara, Takamitsu; Nakamura, Hiroaki; Watanabe, Masashige; Akira Horiuchi Tetrahedron Letters, 2006 , vol. 47, # 52 p. 9359 - 9364

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被引用次数: 24

摘要

A novel reaction of α-halo ketone (α-bromo and α-chloro ketone) with irradiation under microwave gave the corresponding α-hydroxyketone and pyrazine derivative in good yields. In the case of α, α′-dibromo ketone, α-diketone was obtained. This reaction affords a new, clean and convenient synthetic method for α-hydroxyketone, α-diketone, α-chloro ketone and pyrazine derivative.

99-73-0

对-α-二溴苯乙酮

~82%

3343-45-1

1-(4-溴苯基)-2-羟基乙基-1-酮

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~82%

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~73%

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~63%

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~83%

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~66%

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~67%

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~79%

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~76%

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~78%

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~94%

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~71%

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~89%

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~71%

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~84%

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~84%

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~90%

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~86%

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~92%

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~18%

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