Tetrahedron letters

A mild and efficient biomimetic synthesis of α-hydroxymethylarylketones from oxiranes in the presence of β-cyclodextrin and NBS in water

MA Reddy, N Bhanumathi, KR Rao

文献索引：Arjun Reddy; Bhanumathi; Rama Rao Tetrahedron Letters, 2002 , vol. 43, # 17 p. 3237 - 3238

被引用次数: 28

摘要

α-Hydroxymethylarylketones can be synthesized in good yields from easily accessible epoxides in the presence of β-cyclodextrin and NBS in water. This method is a direct, one- pot, synthesis under mild conditions using water as solvent and has many advantages over existing methodologies.

32017-76-8

2-(4-溴苯基)环氧乙烷

~93%

3343-45-1

1-(4-溴苯基)-2-羟基乙基-1-酮

~94%

~97%

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