The Journal of organic chemistry

A convenient synthesis of 2-(alkylamino) pyridines

DM Krein, TL Lowary

文献索引：Krein, Douglas M.; Lowary, Todd L. Journal of Organic Chemistry, 2002 , vol. 67, # 14 p. 4965 - 4967

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被引用次数: 33

摘要

The asymmetric reduction of prochiral ketones by a complex formed from lithium aluminum hydride, (1R,2S)-(−)-N-methylephedrine, and 2-(ethylamino)pyridine (1a, Chart 1) is a useful method for the synthesis of optically pure secondary alcohols. 1,2 In the course of other investigations, we had the need to carry out this reduction on large scale and thus required significant quantities of 1a. ... When choosing among the methods reported for the preparation of ...