Regioselective Generation of Aryllithiums from Substituted Bromobenzenes XC6H4Br (X= 4??Br, 4??I, 4??CN, 2??CN)

…, J Serwatowski, M Szczerbińska

文献索引：Lulinski, Sergiusz; Serwatowski, Janusz; Szczerbinska, Magdalena European Journal of Organic Chemistry, 2008 , # 10 p. 1797 - 1801

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被引用次数: 2

摘要

Abstract Selected activated bromobenzenes XC 6 H 4 Br (X= 4-Br, 4-I, 4-CN, 2-CN) were successfully deprotonated with lithium 2, 2, 6, 6-tetramethylpiperidide (LTMP) in THF at–80 C. Thus, 2, 5-dibromo-, 2-bromo-5-iodo-, 5-bromo-2-cyano-, and 3-bromo-2- cyanophenyllithium were obtained as stable intermediates and could be converted by subsequent reactions into various functionalized derivatives with good yields. A ...