Selective monolithiation of 2, 5-dibromopyridine with butyllithium

…, P Rabbat, P O'Shea, R Tillyer, EJJ Grabowski…

文献索引：Wang, Xin; Rabbat, Philippe; O'Shea, Paul; Tillyer, Richard; Grabowski; Reider, Paul J. Tetrahedron Letters, 2000 , vol. 41, # 22 p. 4335 - 4338

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被引用次数: 92

摘要

Selective monolithiation of 2, 5-dibromopyridine at either the 2-position or the 5-position is reported. Solvent and concentration strongly influence the selectivity. Coordinating solvents and higher concentration favor the 5-position while non-coordinating solvents and lower concentration favor the 2-position.