Synthesis of advanced intermediates of lennoxamine analogues

…, PS Patil, UM Krishna, GK Trivedi, MM Salunkhe

文献索引：Sarang, Prajakta S.; Yadav, Arun A.; Patil, Prashant S.; Krishna, Urlam Murali; Trivedi, Girish K.; Salunkhe, Manikrao M. Synthesis, 2007 , # 7 p. 1091 - 1095

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被引用次数: 14

摘要

In light of the numerous methods known for the synthesis of biologically important isoindolones, [4] we wish to disclose here a simple and convenient method based on the intramolecular Diels-Alder reaction of furan approach to the synthesis of isoindolone derivatives. These isoindolone derivatives could, in turn, be transmuted to lennoxamine and analogues. The retrosynthetic approach of our synthesis is outlined in Scheme [1] . ... Scheme 2 Reagents and conditions: (a) ...