Tetrahedron

The asymmetric synthesis of β-aryl-α-hydroxy esters from β-aryl-α, β-dihydroxy esters

NJ Lawrence, S Brown

文献索引：Lawrence, Nicholas J; Brown, Stephen Tetrahedron, 2002 , vol. 58, # 3 p. 613 - 619

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被引用次数: 10

摘要

α, β-Dihydroxy-β-aryl esters obtained via Sharpless asymmetric dihydroxylation (AD) of substituted cinnamate esters are reduced by sequential reaction with trimethyl orthoacetate and acetyl bromide followed by catalytic hydrogenolysis in methanol to give enantiomerically enriched β-aryl-α-hydroxy esters.