Organic & Biomolecular Chemistry 2011-06-21

Synthesis of novel N-hydroxy heterocycles via intramolecular reductive cyclization of diketoximes by NaBH3CN.

Muthupandi Nagaraj, Muthusamy Boominathan, Shanmugam Muthusubramanian, Nattamai Bhuvanesh

文献索引：Org. Biomol. Chem. 9 , 4642, (2011)

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摘要

A simple and efficient protocol for the construction of substituted piperazines, piperidines, thiomorpholines, decahydroquinolines, perhydrocyclopenta[b]pyridine, and pyrrolidines bearing N-hydroxy substituents through intramolecular reductive cyclization of diketoximes using sodium cyanoborohydride is described.