Generation of the dianion of N-(trimethylsilyl) acetamide and reaction of the dianion with electrophilic reagents

PC Kuzma, LE Brown, TM Harris

文献索引：Kuzma, Peter C.; Brown, Lawrence E.; Harris, Thomas M. Journal of Organic Chemistry, 1984 , vol. 49, # 11 p. 2015 - 2018

全文：HTML全文

被引用次数: 14

摘要

1 sented a potential solution to the problem since the silyl groups can easily be removed by hydrolysis. Condensation with ketones occur in excellent yield, but other reactions including alkylations and, most important for us, acylations are only marginally succe~ sful.~ The enolate anion is thermally unstable; rearrangement to C-silylated derivatives competes with the desired condensation reactions in cases where the electrophile does not react ...