A series of substituted pyridines and purines containing 2, 4-thiazolidinedione were designed and synthesized from their corresponding pyridines and purines. These synthesized compounds (entry no. 6a–d, 12a–e, 18a–d, 23a–c) were evaluated for their effect on triglyceride accumulation in 3T3-L1 cells in vitro and their hypoglycemic and hypolipidemic activity in the genetically diabetic KKAy mice in vivo. On the basis of their ...
[Na, Youngim; Park, Soyoung; Han, Soo Bong; Han, Hoon; Ko, Sangwon; Chang, Sukbok Journal of the American Chemical Society, 2004 , vol. 126, # 1 p. 250 - 258]
