New synthetic routes to 3-, 5-, and 6-aryl-2-chloropyridines

R Church, R Trust, JD Albright…

文献索引：Church; Trust; Albright; Powell Journal of Organic Chemistry, 1995 , vol. 60, # 12 p. 3750 - 3758

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被引用次数: 36

摘要

The efficient synthesis of 3-, 5-, and 6-aryl-2-chloropyridines via the facile preparation of 54 dimethyamin0) aryl-substituted pentadienyl nitriles and cyclization with hydrochloric acid is described. This approach allows for the introduction of other electron-withdrawing substituents on the pyridine ring as well as the preparation of the desired unsubstituted arylpyridines. Some differences in the rates of cyclization of the pentadienyl nitriles as well ...