8-(2-Furyl) adenine derivatives as A 2A adenosine receptor ligands

…, C Lambertucci, A Thomas, KN Klotz, S Federico…

文献索引：Dal Ben, Diego; Buccioni, Michela; Lambertucci, Catia; Thomas, Ajiroghene; Klotz, Karl-Norbert; Federico, Stephanie; Cacciari, Barbara; Spalluto, Giampiero; Volpini, Rosaria European Journal of Medicinal Chemistry, 2013 , vol. 70, p. 525 - 535

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被引用次数: 3

摘要

Abstract Selective adenosine receptor modulators are potential tools for numerous therapeutic applications, including cardiovascular, inflammatory, and neurodegenerative diseases. In this work, the synthesis and biological evaluation at the four human adenosine receptor subtypes of a series of 9-substituted 8-(2-furyl) adenine derivatives are reported. Results show that 8-(2-furyl)-9-methyladenine is endowed with high affinity at the A 2A ...