8-(2-Furyl) adenine derivatives as A 2A adenosine receptor ligands

…, C Lambertucci, A Thomas, KN Klotz, S Federico…

Index: Dal Ben, Diego; Buccioni, Michela; Lambertucci, Catia; Thomas, Ajiroghene; Klotz, Karl-Norbert; Federico, Stephanie; Cacciari, Barbara; Spalluto, Giampiero; Volpini, Rosaria European Journal of Medicinal Chemistry, 2013 , vol. 70, p. 525 - 535

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Citation Number: 3

Abstract

Abstract Selective adenosine receptor modulators are potential tools for numerous therapeutic applications, including cardiovascular, inflammatory, and neurodegenerative diseases. In this work, the synthesis and biological evaluation at the four human adenosine receptor subtypes of a series of 9-substituted 8-(2-furyl) adenine derivatives are reported. Results show that 8-(2-furyl)-9-methyladenine is endowed with high affinity at the A 2A ...