Bioorganic & Medicinal Chemistry Letters
2004-11-15
Aryl urea analogs with broad-spectrum antibacterial activity.
Punit P Seth, Ray Ranken, Dale E Robinson, Stephen A Osgood, Lisa M Risen, Elizabeth L Rodgers, Michael T Migawa, Elizabeth A Jefferson, Eric E Swayze
文献索引：Bioorg. Med. Chem. Lett. 14(22) , 5569-72, (2004)
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摘要
The preparation and evaluation of novel aryl urea analogs as broad-spectrum antibacterial agents is described. Numerous compounds showed low micromolar minimum inhibitory concentrations (MIC) against both Gram-positive and Gram-negative bacteria. Selected analogs also exhibited in vivo efficacy in a lethal murine model of bacterial septicemia.
相关化合物
| 结构式 | 名称/CAS号 | 分子式 | 全部文献 |
|---|---|---|---|
 |
3,5-二溴苯甲醛
CAS:56990-02-4 |
C7H4Br2O |
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